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What is Hirschsprung Disease? Print E-mail
Written by Jessica Smith   
Tuesday, 20 October 2009
Hirschsprung disease is a blockage in the large intestine. It is caused by an lack of nerve cells in a portion of the intestine. A person is born with this condition.

What is going on in the body?
A person with this disease is missing the nerve cells known as ganglia in part or all of the large bowel. These cells are absent at birth. The normal function of these cells is to enable the bowel muscle to contract. This motion pushes the stool through the intestine. Stool cannot pass through the segment of the bowel where the nerves are missing. As a result, stool collects at that point causing an intestinal blockage.

What are the causes and risks of the disease?
This disease is present at birth. It occurs because some nerve cells fail to develop in portions of the large bowel while the fetus is growing in the uterus. This disease may be inherited. Most of the time, however, the cause is unknown. It is more common in boys than girls. This disease may also be associated with other conditions that are present at birth such as Down syndrome.

What are the treatments for the disease?

Most people with this disease will need surgery. Usually, the affected part of the bowel is removed. Surgery is often a two-part process. A procedure called a colostomy often the first step. During the colostomy, the bowel is divided and the affected portion removed. The surgeon then creates a hole in the skin of the abdomen, known as a stoma. The top part of the bowel is connected to the stoma. Stool can then leave the body through this opening while the lower part of the bowel heals. Once the lower bowel has healed, a second surgery can be done to reconnect it to the rest of the intestine. The stoma will then be closed and normal bowel movements should resume. Fluids may be given through a vein during and after surgery. Antibiotics may also be administered to prevent or treat infection in the bowels.

What are the side effects of the treatments?
Any surgery has possible side effects. These may include bleeding, infection, and allergic reactions to pain medications. If antibiotics are used, they may cause stomach upset or allergic reactions. Some people experience involuntary loss of stool after the surgery.

What happens after treatment for the disease?

After surgery, symptoms usually go away. Most children are able to have normal bowel movements after surgery. In general, the earlier a person receives treatment, the better the outcome.

How is the disease monitored?
The child's caregiver should contact a healthcare provider right away if new or worsening symptoms occur after surgery.


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